教 師 簡 歷
基本信息
照片/Photo：
電子郵箱/E-mail：wanggh168@yggyf.cn
個人簡介
王根洪🌐： 研究員、碩士生導師
1999-2003 西南農業大學 本科生
2003-2008 西南農業大學（西南大學） 博士生（碩博連讀）
2008-2012 重慶大學農學及生命科學研究院 講師
2012-2023 西南大學副研究員
2014-2016 美國康奈爾大學附屬BTI研究所訪問學者
2023至今 西南大學研究員
主要科研領域與方向1. 基於昆蟲-植物互作的動物營養利用調控機製研究
從鱗翅目昆蟲-植物二元系統協同進化關系入手，整合基因組學、分子生物學➖、遺傳學和生物化學等研究手段🏌️♀️，系統研究調控昆蟲進食和營養消化的分子機製，為提升有益昆蟲（家蠶）營養利用效率和防控有害昆蟲提供思路和分子靶標。比較分析昆蟲與哺乳動物營養利用調控機製的異同點，開發調節動物飽腹感及體重增減等與人類健康緊密相關的高附加值生物製劑🪨🧙🏽♂️。
2. 基於基因工程的植物品種素材創製
在解析植物抗蟲🤵🏽、抗逆等分子調控機製的基礎上🏋️，通過CRISPR/Cas9基因編輯、過表達等手段對相應基因表達水平進行調控，在現行植物品種上定向創製更加優良的品種素材。
科學成就1. 建立了基於轉基因RNAi和增量表達抗病毒蛋白的家蠶抗病分子育種技術體系🌌，製作獲得了對家蠶核型多角體病毒（BmNPV）具有增強抗性的轉基因家蠶素材數個🦸🏿。
2. 作為主研人員🧏♀️🖕🏿，全程參與了家蠶全基因組基因芯片的研製。參加了西南大學主持的家蠶基因組計劃及“十一五”🪣、“十二五”家蠶“973”、“863”、“948”及國家自然科學基金重點項目☘️。
3. 主持國家重點研發計劃子課題🐹、國家自然科學基金、重慶市自然科學基金🚅、重慶市基礎科學與前沿技術研究項目、中央高校科研業務費等各類科研項目20余項。近年來已在國內外高水平期刊發表論文30余篇，參與編寫專著2部🧝🏿♀️；獲得專利授權10余項🤮，其中第一專利權人7項🤏🏻。任教育部學位論文評審專家及全國研究生教育評估監測專家🧗🏼♂️。
代表性論文/論著
1. Bingchuan Bai,† Yuchan Wen,† Jing Wang, Feng Wen, Hao Yan, Xingli Yuan, Jiatong Xie, Ruihan Zhang, Qingyou Xia, # and Genhong Wang#(Corresponding author) (2024). Fatty Acid Desaturase Bmdesat5, Suppressed in the Salivary Glands by Domestication, is Involved in Regulation of Food Intake in Silkworms. Journal of Agricultural and Food Chemistry. 2024, 72, 14177−14190.
2. Wen Feng, Wang Jing, Shang Deli, Yan Hao, Yuan Xingli, Wang Yuanqiang, Xia Qingyou, Genhong Wang#(Corresponding author) (2023). Non-classical digestive lipase BmTGL selected by gene amplification reduces the effects of mulberry inhibitor during silkworm domestication. International Journal of Biological Macromolecules, 229 (2023) 589–599.
3. Liu Lijing, Zhao Dongchao, Wang Genhong, He Qingxiu, Song Yuwei, Jiang Yulu, Xia Qingyou and Zhao Ping (2023). Adaptive Changes in Detoxification Metabolism and Transmembrane Transport of Bombyx mori Malpighian Tubules to Artificial Diet. Int. J. Mol. Sci., 2023, 24, 9949.
4. Chen,Wenwen, Wang Genhong, Yi Meiqin, Gao Tianke, Song Chunman, Gao Qian, Xia Qingyou, Xiang Haiying (2023). Whole‑genome identification and salt‑ and ABA‑induced expression trends of the Nicotiana tabacum CKX gene family. Plant Biotechnology Reports, 17:389–399.
5. Yan Hao🏊🏻，Wen Feng，Xiang Haiying，Wen Yuchan，Shang Deli💪🏻，Liu Anyang， Niu Yicheng，Xia Qingyou, Wang Genhong#(Corresponding author) (2022). Biochemical characterization and overexpression of an α-amylase (BmAmy) in silkworm, Bombyx mori. Insect Molecular Biology, 31:251–259.
6. Li Zhaowu, Gao Junping, Wang Genhong, Wang Shuaibin, Chen Kai, Pu Wenxuan, Wang Yaofu, Xia Qingyou＃ and Fan Xiaorong＃(2022). Genome-Wide Identification and Characterization of GASA Gene Family in Nicotiana tabacum. Frontiers in Genetics, 12 , Article 768942
7. Yan Hao, Liu qingsong, Wen feng, Bai bingchuan, Wen Yuchan, Chen Wenwen, Lu Wei, Lin Ying, Xia Qingyou, Wang Genhong #(Corresponding author) (2021). Characterization and potential application of an α-amylase (BmAmy1) selected during silkworm domestication. International Journal of Biological Macromolecules, 167 (2021) 1102–1112.
8. Li Yueyue, Zhao min, Chen Wenwen, Du Hongyi, Xie Xiaodong, Wang Daibin, Dai Ya, Xia Qingyou, Wang Genhong# (Corresponding author) (2020). Comparative transcriptomic analysis reveals that multiple hormone signal transduction and carbohydrate metabolic pathways are affected by Bacillus cereus in Nicotiana tabacum. Genomics, 112, 4254–4267.
9. DaoYuan Qin, Genhong Wang, ZhaoMing Dong, QingYou Xia, Ping Zhao (2020). Comparative Fecal Metabolomes of Silkworms Being Fed Mulberry Leaf and Artificial Diet. Insects, 30;11(12):851.
10. Chen Yanfei, Bai Bingchuan, Yan Hao, Wen Feng, Qin Daoyuan, Jander Georg, Xia Qingyou, Wang Genhong#(Corresponding author) (2019). Systemic disruption of the homeostasis of transfer RNA isopentenyltransferase causes growth and development abnormalities in Bombyx mori. Insect molecular biology, 28(3), 380–391.
11. Li Yueyue, Bai Bingchuan, Wen Feng, Zhao Min, Xia Qingyou, Yang Da-Hai*, and Genhong Wang*(Corresponding author) (2019). Genome-Wide Identification and Expression Analysis of HD-ZIP I Gene Subfamily in Nicotiana tabacum. Genes, 10(8): 575.
12.Wang Genhong, Chen Yanfei, Zhang Xiaoying, Bai Bingchuan, Yan Hao, Qin Daoyuan, Xia Qingyou (2018). Selection of reference genes for tissue/organ samples on day 3 fifth-instar larvae in silkworm, Bombyx mori. Arch Insect Biochem Physiol 98(2), e21458.
13. Wang Genhong, Wang Pei, Gao Yulong, Li Yueyue, Wu Lei, Gao Junping, Zhao Min, Xia Qingyou (2018). Isolation and functional characterization of a novel FLOWERING LOCUS T homolog (NtFT5) in Nicotiana tabacum. Journal of plant physiology. 2018;231:393-401.
14.Wu Lei, Zhang Xiaoying, Xu Bingxin, Li Yueyue, Jia Ling, Wang Rengang, Ren Xueliang, Wang Genhong#(Corresponding author), Xia Qingyou (2018). Identification and expression analysis of EDR1-like genes in tobacco (Nicotiana tabacum) in response to Golovinomyces orontii. PeerJ 6, e5244.
15. Xingtan Zhang, Genhong Wang, Junping Gao, Mengyu Nie, Wenshan Liu and Qingyou Xia (2016) Functional analysis of NtMPK2 uncovers its positive role in response to Pseudomonas syringae pv. tomato DC3000 in tobacco. Plant Mol Biol, 90, 19-31.
16. Junping Gao, Genhong Wang＃ (Co-first author), Sanyuan Ma, Xiaodong Xie, Xiangwei Wu, Xingtan Zhang, Yuqian Wu, Ping Zhao and Qingyou Xia (2015). CRISPR/Cas9-mediated targeted mutagenesis in Nicotiana tabacum. Plant Mol Biol, 87, 99-110.
17. Xiaodong Xie, Genhong Wang＃ (Co-first author), Ling Yang, Tingcai Cheng, Junping Gao, Yuqian Wu and Qingyou Xia (2015). Cloning and characterization of a novel Nicotiana tabacum ABC transporter involved in shoot branching. Physiol Plant, 153, 299-306.
18. Xingtan Zhang, Mengyun Nie, Qian Zhao, Yuqian Wu, Genhong Wang and Qingyou Xia (2015) Genome-wide patterns of genetic variation among silkworms. Mol Genet Genomics, 290, 1575-87.
19. Genhong Wang, Liang Jiang, Li Zhu, Ting-Cai Cheng, Wei-Huan Niu, Ya-Fei Yan and Qing-You Xia.(2013). “Characterization of Argonaute family members in the silkworm, Bombyx mori.” Insect Science. 00:1-14.
20. Jiang, L., P. Zhao, T. Cheng, Q. Sun, Z. Peng, Y. Dang, X. Wu, G. Wang, S. Jin, P. Lin & Q. Xia (2013) A transgenic animal with antiviral properties that might inhibit multiple stages of infection. Antiviral Res, 98, 171-3.
21. Xiaodong Xie, Tingcai Cheng, Genhong Wang, Jun Duan, Weihuan Niu and Qingyou Xia (2012) Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in the silkworm, Bombyx mori. Mol Biol Rep, 39, 7281-91.
22. Jiang, L., G. Wang, T. Cheng, Q. Yang, S. Jin, G. Lu, F. Wu, Y. Xiao, H. Xu and Q. Xia (2012). "Resistance to Bombyx mori nucleopolyhedrovirus via overexpression of an endogenous antiviral gene in transgenic silkworms." Arch Virol.
23. Zhao, P., Z. Dong, J. Duan, G. Wang, L. Wang, Y. Li, Z. Xiang and Q. Xia (2012). "Genome-wide identification and immune response analysis of serine protease inhibitor genes in the silkworm, Bombyx mori." PLoS One 7(2): e31168.
24. Jiang, L., T. Cheng, P. Zhao, Q. Yang, G. Wang, S. Jin, P. Lin, Y. Xiao & Q. Xia (2012) Resistance to BmNPV via overexpression of an exogenous gene controlled by an inducible promoter and enhancer in transgenic silkworm, Bombyx mori. PLoS One, 7, e41838.
25. Jiang, L., P. Zhao, G. Wang, T. Cheng, Q. Yang, S. Jin, P. Lin, Y. Xiao, Q. Sun & Q. Xia (2012) Comparison of factors that may affect the inhibitory efficacy of transgenic RNAi targeting of baculoviral genes in silkworm, Bombyx mori. Antiviral Res, 97, 255-263.
26. Xingtan Zhang, Tingcai Cheng, Genhong Wang, Yafei Yan, Qingyou Xia(2012). Cloning and evolutionary analysis of tobacco MAPK gene family. Mol Biol Rep. DOI 10.1007/s11033-012-2184-9.
27. Zhao, P., Genhong Wang, Z. M. Dong, J. Duan, P. Z. Xu, T. C. Cheng, Z. H. Xiang and Q. Y. Xia (2010). "Genome-wide identification and expression analysis of serine proteases and homologs in the silkworm Bombyx mori." BMC Genomics 11: 405.
28. Genhong Wang, Chun Liu, Xing-fu Zha, Jie Chen, Liang Jiang and Q.-y. Xia. (2008). "Cathepsin B protease is required for metamorphism in silkworm, Bombyx mori." Insect Science 15: 201-208.
29. Genhong Wang, Qing-You Xia, Dao-Jun Cheng, Jun Duan, Ping Zhao, Jie Chen and Z. Li. (2008). "Reference genes identified in the silkworm Bombyx mori during metamorphism based on oligonucleotide microarray and confirmed by qRT-PCR." Insect Science 15: 405-413.
30. The International Silkworm Genome, C. (2008) The genome of a lepidopteran model insect, the silkworm Bombyx mori. Insect Biochem Mol Biol, 38, 1036-45. (the 28th author in the Chinese group).
31. Cheng, D., Q. Xia, J. Duan, L. Wei, C. Huang, Z. Li, G. Wang and Z. Xiang (2008). "Nuclear receptors in Bombyx mori: Insights into genomic structure and developmental expression." Insect Biochem Mol Biol 38(12): 1130-7.
32. Qingyou Xia, Daojun Cheng, Jun Duan, Genhong Wang, Tingcai Cheng, Xingfu Zha, Chun Liu, Ping Zhao, Fangyin Dai, Ze Zhang, Ningjia He, Liang Zhang and Zhonghuai Xiang (2007). "Microarray-based gene expression profiles in multiple tissues of the domesticated silkworm, Bombyx mori." Genome Biol 8(8): R162.
33. 王根洪, 祝慧敏, 羅會松, 王軻軻, 楊小波, 蔣亮, 夏慶友 (2011). "細菌表達dsRNA介導的家蠶FTZ-F1基因的RNA幹擾." 昆蟲學報 54(5): 596-601.
34. 王根洪, 劉春, 楊遠萍, 吳雪峰, 夏慶友 (2005). "siRNA介導的家蠶ABC轉運蛋白相關基因的幹涉研究." 蠶業科學(2): 117-120,i001.
35. 艾均文, 王根洪, 李艷紅, 余泉友, 張學松, 朱勇, 向仲懷. (2008). "家蠶P450基因CYP18A1的克隆、序列分析及其表達譜研究." 昆蟲學報 3: 237-245.
36.王振興, 王璞, 姚玲, 曾智東, 徐漢福, 段軍, 王根洪, 夏慶友 (2006). "家蠶細胞凋亡相關基因BmlCAD的克隆、序列和功能分析及其在精巢中特異表達的初步研究." 遺傳(7): 838-844.
37. 徐漢福, 王 峰, 王根洪, 段曉利, 馬三垣, 夏慶友 (2011). "家蠶Poly(A)結合蛋白基因BmPABP的克隆及序列與功能分析." 蠶業科學 37(3): 412-418.
38. 楊遠萍, 劉春, 王子龍, 王根洪, 夏慶友 (2006). "家蠶組織蛋白酶D基因的克隆🧑🏿🦳🎱、序列分析及其表達譜研究." 昆蟲學報(2): 172-178.
聯系地址：重慶市北碚區西南大學（南區）蠶學宮410室，400715
電 話🧠： 023-68251573
E-mail：wanggh168@yggyf.cn
