教 師 簡 歷
基本信息
照片/Photo:
電子郵箱/E-mail:jiangbosong@yggyf.cn
個人簡介
致力於家蠶分子生理學及實驗動物化研究,並以壽命調控、延壽藥物評價和疾病模型構建為主要內容,推進家蠶模式化應用🤽🏿♂️。主持國家自然科學基金項目2項(面上🦿、青年各1項)、西南大學基礎學科“U40”青年人才科技項目等各類科研項目6項👨🏿🍼。以第一作者發表SCI論文11篇(大類一區5篇)🧑🚀,發現長壽調節新基因OSER1👨🏿🦲,闡明了其在多個物種中響應氧化應激的作用機理🧛🏿♀️,揭示了其抗衰延壽的保守性新機製,為推動家蠶作為探究人類衰老與疾病研究的實驗動物奠定了重要基礎,該項成果已被Nature子刊Nat Commun接受💁♂️。此外😶,研究建立了家蠶作為延壽中藥效應評價系統和帕金森綜合症家蠶模型🍲,分別發表在BMC Med(1區😜,IF=11.8)、J Pharm Anal(1區,IF=14.02)、Aging Dis(1區👨🏿✈️,IF=9.96)等知名期刊。申請國家發明專利1項🏋🏿♀️。積極推動國際合作,籌措舉行國際學術研討會2次;承辦國內區域性學術會聯會1次💆🏼♂️🥷🏿,做國際學術報告5次,國內學術報告1次。為國家蠶桑產業技術體系高產優質品種改良崗位團隊成員、《農業生物技術學報》青年編委、重慶市昆蟲學會理事👸🏼👩❤️👨、中國遺傳學會會員👨🏼🦰、BMC Genomics等期刊審稿人。
課程教學
本科生課程:
1. 生物化學與分子生物學基礎(英文),課程負責人🏋️,天辰娱乐平台
2. 細胞工程(雙語),課程負責人,天辰娱乐平台
3. 生命科學前沿,課程參與人🧵🌠,天辰娱乐平台
研究方向及課題
1. 以家蠶為研究對象♦️,結合經典模式動物探究衰老和壽命調節的保守性分子機製
2. 以家蠶為實驗動物發掘疾病基因,構建疾病模型、評價藥物藥效和藥理
研究成果
代表性科研項目:
[1] 國家自然科學基金面上項目,項目名稱:BmOSER1通過調節氧化應激影響雄蠶蛾育性的分子機理研究👰🏻,課題編號:32272939👩🏼⚕️,起止年月:2023.01-2026.12,主持👱🏻♀️。
[2] 國家自然科學基金青年基金項目,項目名稱:BmFoxO靶基因BmOSER1在家蠶氧化壓力應答中的功能及作用機製研究🎒⏸,課題編號🗂:20192215,起止年月:2020.01-2022.12🙆🏿♀️,主持。
[3] 重慶市博士後科研特別資助項目,項目名稱:基於特定motif的FoxO靶基因的全基因組鑒定和功能研究🎻,課題編號📍:Xm2018058🏈🤱🏽;起止年月:2018.10-2020.06;主持。
[4] 西南大學中央高校基本科研業務費基礎學科青年人才項目(簡稱U40),項目名稱➾:“生命蠶”——利用家蠶挖掘壽命調控新基因,課題編號🧝🏿♂️:SWU-KU24007🥿;起止年月:2024.07-2027.06,主持🛥🫳🏻。
[5] 中央高校基本業務費一般項目🎁,項目名稱👽:二甲雙胍調控家蠶壽命的分子機製研究,課題編號:XDJK2019C014;起止年月🙍🏽♂️:2019.03-2020.12😯✌🏿;主持🧛🏻。
[6] 西南大學博士啟動(含引進人才計劃)項目,項目名稱👸🏼:OSER1基因調控壽命的機製研究,課題編號📳:SWU120064;起止年月:2021.05-2022.12;主持。
代表性學術論文:
[1] Jiangbo Song*, Zhiquan Li*, Lei Zhou, Xin Chen, Wei Qi Guinevere Sew, Héctor Herranz, Zilu Ye, Jesper Velgaard Olsen, Yuan Li, Marianne Nygaard, Kaare Christensen, Xiaoling Tong, Vilhelm A. Bohr, Lene Juel Rasmussen§, Fangyin Dai§. FOXO-regulated OSER1 reduces oxidative stress and extends lifespan in multiple species. Nature Communications. 2024, In production.
[2] Song Jiangbo*, Liu Lian*, Li Zhiquan *, Mao Ting, Zhang Jianfei, Zhou Lei, Chen Xin, Shang Yunzhu, Sun Tao, Luo Yuxin, Jiang Yu, Tan Duan, Tong Xiaoling and Dai Fangyin§. Lycium barbarum polysaccharide improves dopamine metabolism and symptoms in an MPTP-induced model of Parkinson’s disease. BMC Medicine. 2022, 20: 412. Doi:10.1186/s12916-022-02621-9
[3] Song Jiangbo*, Chen Min*, Li Zhiquan, Zhang Jianfei, Hu Hai, Tong Xiaoling§, Dai Fangyin§. Astragalus Polysaccharide extends lifespan via mitigating endoplasmic reticulum stress in the Silkworm, Bombyx mori. Aging and Disease. 2019, 10(2): 1187-1198.
[4] Song Jiangbo*, Liu Lian*, Hao Kaige, Mao Shuang, Tang Yongxi, Tong Xiaoling, Dai Fangyin§. Resveratrol elongates the lifespan and improves antioxidant activity in the silkworm, Bombyx mori. Journal of Pharmaceutical Analysis. 2021, 11: 374-382.
[5] Song Jiangbo*, Jiang Guihua*, Zhang Jianfei, Guo Jieshu, Li Zheng, Hao Kaige, Liu Lian, Cheng Zilin, Tong Xiaoling, Dai Fangyin§. Metformin prolongs lifespan through remodeling the energy distribution strategy in silkworm, Bombyx mori. Aging-US, 2019, 11(1): 240-248.
[6] Song Jiangbo*, Hao Kaige*, Chen Xin, Zhang Yanhua, Cheng Zilin, Mao Shuang, Tang Yongxi, Tong Xiaoling and Dai Fangyin§. Fibroblast growth factor 21 prolongs lifespan and improves stress tolerance in the silkworm, Bombyx mori. Annals of Translational Medicine. 2020, 8(5): 220.
[7] Song Jiangbo*, Li Zhiquan*, Tong Xiaoling, Chen Cong, Chen Min, Meng Gang, Chen Peng, Li Chunlin, Dai Fangyin§. Genome-wide identification and characterization of Fox genes in the silkworm, Bombyx mori. Functional & Integrative Genomics. 2015, 15(5):511-522.
[8] Song Jiangbo, Zhang Jianfei, Dai Fangyin§. Advantages and limitations of silkworm as an invertebrate model in aging and lifespan research. Invited, Open Access Journal of Gerontology & Geriatric Medicine. 2018, 4(4): ID.555641.
[9] Zhiquan Li*, Jiangbo Song*, Guihua Jiang, Yunzhu Shang, Yu Jiang, Jianfei Zhang, Li Xiao, Min Chen, Dongmei Tang, Xiaoling Tong, Fangyin Dai§. Juvenile hormone suppresses the FoxO-takeout axis to shorten longevity in male silkworm. Pesticide Biochemistry and Physiology. 2023, 192: 105388.
[10] Jianfei Zhang*, Zhiquan Li*, Jiangbo Song*, Lei Zhou, Xin Chen, Wen Ge, Tianyi Dong, Yuxin Luo, Ting Mao, Zheng Li, Duan Tan, Lene Juel Rasmussen, Vilhelm A. Bohr, Xiaoling Tong, Fangyin Dai§. Salidroside promotes healthy longevity by interfering with HSP90 activity. GeroScience. 2023, Accepted.
[11] Chen Cong*, Song Jiangbo*, Chen Min, Li Zhiquan, Tong Xiaoling, Hu Hai, Xiang Zhonghuai, Lu Cheng, Dai Fangyin§. Rhodiola rosea extends lifespan and improves stress tolerance in silkworm, Bombyx mori. Biogerontology. 2016, 17: 373-381.
[12] Jiang Guihua, Song Jiangbo, Hu Hai, Tong Xiaoling and Dai Fangyin§. evalsuation of the silkworm lemon mutant as an invertebrate animal model for human sepiapterin reductase deficiency. Royal Society Open Science. 2020, 7(3): 191888.
[13] Li Zheng, Song Jiangbo, Zhang Jianfei, Hao Kaige, Liu Lian, Wu Boqing, Zheng Xinyue, Xiao Bo, Tong Xiaoling, Fangyin Dai§. Topical application of silk fibroin-based hydrogel in preventing hypertrophic scars. Colloids and Surfaces B-Biointerfaces. 2019, 186: 110735.
授權專利🚯:
[1] 專利權人:代方銀🧙🏽♂️、宋江波、李知泉🧑🏿🦳、陳欣💿、童曉玲🚣、周磊、韓民錦、胡海🌑,專利名稱🤦🏼:OSER1基因在提升動物生殖力或延緩生殖衰老中的應用和方法,專利類型:發明專利,授權號:ZL 2022 1 0988437.5,授權時間:2024-04-05,國別:中國🫑。
學術報告☝🏻🤹🏼:
1. 2024 Conference on Healthy Aging, Chongqing, China, Topic: Silkworm: a promising experimental animal for aging and lifespan study, June 17th-19th, 2024.
2. 2023 SWU-UCPH Bilateral Academic Conference, Chongqing, China, Topic: The progress in silkworm experimental Biological Systems, October 19th-23rd, 2023.
3. The 7th Asia-Pacific Congress of Sericulture and Insect Biotechnology, Zhenjiang, China, Topic: FOXO-regulated OSER1 reduces oxidative stress and extends lifespan in multiple species, August 18th-22nd, 2023.
4. The 6th Asia-Pacific Congress of Sericulture and Insect Biotechnology, Mysore, India, Topic: Death-3, a newly identified FoxO target regulates lifespan in silkworm, Bombyx mori, March 1st-5th, 2019.
5. The Sino-Korea Joint Symposium on Insect Molecular Biology and Biotechnology, Jiangsu, China, Topic: Identification of FoxO target gene OSER1 and its functional study on lifespan in silkworm, Bombyx mori. December 6th-8th, 2019.
6. 第九屆中國蠶學會青年學術研討會,重慶,中國,報告題目🦵:BmFoxO基因調控壽命的初步研究。2017年10月。
學術任職:
1. 重慶市昆蟲學會,理事,2023.09-至今
2. 中國遺傳學會🤘🏼,會員🧝🏽♀️,2023.11-至今
3. 農業生物技術學報,青年編委,2024.01-至今
4. 國家蠶桑產業技術體系高產優質品種改良崗位團隊成員😨,2023.01 -至今
5. 擔任BMC Genomics等期刊審稿人